Evidence-Based Relief, Backed by Science

Topics:

• Combination Therapy - General
• Combination Therapy - Antihistamine + Anti-Inflammatory Corticosteroid
• Combination Therapy - Decongestant + Anti-Inflammatory Corticosteroid
• Combination Therapy - Anti-Discharge + Anti-Inflammatory Corticosteroid
• Combination Therapy - Anti-Discharge + Decongestant
• Active Ingredient - Anti-Inflammatory Corticosteroid
• Active Ingredient - Micro-Dosed Decongestant
• Active Ingredient - Anti-Discharge
• Active Ingredient - Antihistamine
• Active Ingredient - Nasal Saline

The Study of a Novel Triple Spray Combination of Corticosteroid, Antihistamine and Decongestant Delivered in a Single Spray

Category: Combination Therapy - General

Study Link: https://www.jacionline.org/article/S0091-6749(20)32244-2/fulltext

Overview:

This study evaluated a novel triple spray composed of triamcinolone (a corticosteroid), azelastine (an antihistamine), and oxymetazoline (a decongestant) delivered in a single formulation. The goal was to determine whether this combination offered superior symptom relief for allergic rhinitis (AR) compared to the use of a single-agent nasal spray.

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The Takeaways:

• The triple spray group reported a statistically significant improvement in sinus pressure relief compared to those using a single nasal spray (p = 0.039).
• The triple spray did not lead to increased adverse effects, suggesting good tolerability.
• Preliminary findings support the efficacy of combining anti-inflammatory, antihistamine, and decongestant agents in a single spray for improved symptom control, particularly sinus pressure. </aside>